Inducible but Not Constitutive Expression of PD-L1 in Human Melanoma Cells Is Dependent on Activation of NF-κB

Monoclonal antibodies against immune checkpoint blockade have proven to be a major success in the treatment of melanoma. The programmed death receptor-1 ligand-1 (PD-L1) expression on melanoma cells is believed to have an inhibitory effect on T cell responses and to be an important escape mechanism...

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Detalles Bibliográficos
Autores principales: Gowrishankar, Kavitha, Gunatilake, Dilini, Gallagher, Stuart J., Tiffen, Jessamy, Rizos, Helen, Hersey, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386825/
https://www.ncbi.nlm.nih.gov/pubmed/25844720
http://dx.doi.org/10.1371/journal.pone.0123410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386825/
https://www.ncbi.nlm.nih.gov/pubmed/25844720
http://dx.doi.org/10.1371/journal.pone.0123410

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