The role of hexokinase in cardioprotection – mechanism and potential for translation

Mitochondrial permeability transition pore (mPTP) opening plays a critical role in cardiac reperfusion injury and its prevention is cardioprotective. Tumour cell mitochondria usually have high levels of hexokinase isoform 2 (HK2) bound to their outer mitochondrial membranes (OMM) and HK2 binding to...

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Detalles Bibliográficos
Autores principales: Halestrap, Andrew P, Pereira, Gonçalo C, Pasdois, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386983/
https://www.ncbi.nlm.nih.gov/pubmed/25204670
http://dx.doi.org/10.1111/bph.12899