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Enhanced GABAergic synaptic transmission at VLPAG neurons and potent modulation by oxycodone in a bone cancer pain model
BACKGROUND AND PURPOSE: We demonstrated previously that oxycodone has potent antinociceptive effects at supraspinal sites. In this study, we investigated changes in neuronal function and antinociceptive mechanisms of oxycodone at ventrolateral periaqueductal gray (VLPAG) neurons, which are a major s...
Autores principales: | Takasu, Keiko, Ogawa, Koichi, Nakamura, Atsushi, Kanbara, Tomoe, Ono, Hiroko, Tomii, Takako, Morioka, Yasuhide, Hasegawa, Minoru, Shibasaki, Masahiro, Mori, Tomohisa, Suzuki, Tsutomu, Sakaguchi, Gaku |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BlackWell Publishing Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386988/ https://www.ncbi.nlm.nih.gov/pubmed/25521524 http://dx.doi.org/10.1111/bph.13039 |
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