A regimen combining the Wee1 inhibitor AZD1775 with HDAC inhibitors targets human acute myeloid leukemia cells harboring various genetic mutations

AZD1775 targets the cell cycle checkpoint kinase Wee1 and potentiates genotoxic agent cytotoxicity through p53-dependent or -independent mechanisms. Here, we report that AZD1775 interacted synergistically with histone deacetylase inhibitors (HDACIs e.g., Vorinostat), which interrupt the DNA damage r...

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Detalles Bibliográficos
Autores principales: Zhou, Liang, Zhang, Yu, Chen, Shuang, Kmieciak, Maciej, Leng, Yun, Lin, Hui, Rizzo, Kathryn A., Dumur, Catherine I., Ferreira-Gonzalez, Andrea, Dai, Yun, Grant, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387110/
https://www.ncbi.nlm.nih.gov/pubmed/25283841
http://dx.doi.org/10.1038/leu.2014.296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387110/
https://www.ncbi.nlm.nih.gov/pubmed/25283841
http://dx.doi.org/10.1038/leu.2014.296

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