Loss of the tumor suppressor Hace1 leads to ROS-dependent glutamine addiction

Cellular transformation is associated with altered glutamine (Gln) metabolism. Tumor cells utilize Gln in the tricarboxylic acid (TCA) cycle to maintain sufficient pools of biosynthetic precursors to support rapid growth and proliferation. However, Gln metabolism also generates NADPH, and Gln-derive...

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Detalles Bibliográficos
Autores principales: Cetinbas, Naniye, Daugaard, Mads, Mullen, Andrew, Hajee, Shamil, Rotblat, Barak, Lopez, Alejandra, Li, Amy, DeBerardinis, Ralph J, Sorensen, Poul H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387113/
https://www.ncbi.nlm.nih.gov/pubmed/25284589
http://dx.doi.org/10.1038/onc.2014.316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387113/
https://www.ncbi.nlm.nih.gov/pubmed/25284589
http://dx.doi.org/10.1038/onc.2014.316

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