Integrating dynamic mixed-effect modelling and penalized regression to explore genetic association with pharmacokinetics

CONTEXT: In a previous work, we have shown that penalized regression approaches can allow many genetic variants to be incorporated into sophisticated pharmacokinetic (PK) models in a way that is both computationally and statistically efficient. The phenotypes were the individual model parameter esti...

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Detalles Bibliográficos
Autores principales: Bertrand, Julie, De Iorio, Maria, Balding, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387202/
https://www.ncbi.nlm.nih.gov/pubmed/25751396
http://dx.doi.org/10.1097/FPC.0000000000000127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387202/
https://www.ncbi.nlm.nih.gov/pubmed/25751396
http://dx.doi.org/10.1097/FPC.0000000000000127

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