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Integrating dynamic mixed-effect modelling and penalized regression to explore genetic association with pharmacokinetics
CONTEXT: In a previous work, we have shown that penalized regression approaches can allow many genetic variants to be incorporated into sophisticated pharmacokinetic (PK) models in a way that is both computationally and statistically efficient. The phenotypes were the individual model parameter esti...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Lippincott Williams & Wilkins
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387202/ https://www.ncbi.nlm.nih.gov/pubmed/25751396 http://dx.doi.org/10.1097/FPC.0000000000000127 |