Hematopoietic stem cell quiescence and function are controlled by the CYLD–TRAF2–p38MAPK pathway

The status of long-term quiescence and dormancy guarantees the integrity of hematopoietic stem cells (HSCs) during adult homeostasis. However the molecular mechanisms regulating HSC dormancy remain poorly understood. Here we show that cylindromatosis (CYLD), a tumor suppressor gene and negative regu...

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Detalles Bibliográficos
Autores principales: Tesio, Melania, Tang, Yilang, Müdder, Katja, Saini, Massimo, von Paleske, Lisa, Macintyre, Elizabeth, Pasparakis, Manolis, Waisman, Ari, Trumpp, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387289/
https://www.ncbi.nlm.nih.gov/pubmed/25824820
http://dx.doi.org/10.1084/jem.20141438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387289/
https://www.ncbi.nlm.nih.gov/pubmed/25824820
http://dx.doi.org/10.1084/jem.20141438

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