Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm

Activation-induced deaminase (AID) initiates mutagenic pathways to diversify the antibody genes during immune responses. The access of AID to the nucleus is limited by CRM1-mediated nuclear export and by an uncharacterized mechanism of cytoplasmic retention. Here, we define a conformational motif in...

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Detalles Bibliográficos
Autores principales: Methot, Stephen P., Litzler, Ludivine C., Trajtenberg, Felipe, Zahn, Astrid, Robert, Francis, Pelletier, Jerry, Buschiazzo, Alejandro, Magor, Brad G., Di Noia, Javier M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387293/
https://www.ncbi.nlm.nih.gov/pubmed/25824822
http://dx.doi.org/10.1084/jem.20141157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387293/
https://www.ncbi.nlm.nih.gov/pubmed/25824822
http://dx.doi.org/10.1084/jem.20141157

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