Cargando…

Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm

Activation-induced deaminase (AID) initiates mutagenic pathways to diversify the antibody genes during immune responses. The access of AID to the nucleus is limited by CRM1-mediated nuclear export and by an uncharacterized mechanism of cytoplasmic retention. Here, we define a conformational motif in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Methot, Stephen P., Litzler, Ludivine C., Trajtenberg, Felipe, Zahn, Astrid, Robert, Francis, Pelletier, Jerry, Buschiazzo, Alejandro, Magor, Brad G., Di Noia, Javier M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387293/ https://www.ncbi.nlm.nih.gov/pubmed/25824822 http://dx.doi.org/10.1084/jem.20141157

Ejemplares similares

Non-translational Connections of eEF1B in the Cytoplasm and Nucleus of Cancer Cells
por: Negrutskii, Boris
Publicado: (2020)

Novel regulation of the eEF2K/eEF2 pathway: prospects of ‘PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation’
por: Shen, Yuqian, et al.
Publicado: (2021)

Coordination of changes in expression and phosphorylation of eukaryotic elongation factor 2 (eEF2) and eEF2 kinase in hypertrophied cardiomyocytes
por: Kameshima, Satoshi, et al.
Publicado: (2016)

Rpl24(Bst) mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K
por: Knight, John RP, et al.
Publicado: (2021)

On the Need to Tell Apart Fraternal Twins eEF1A1 and eEF1A2, and Their Respective Outfits
por: Mills, Alberto, et al.
Publicado: (2021)

Analysis of the Expression and Subcellular Distribution of eEF1A1 and eEF1A2 mRNAs during Neurodevelopment
por: Wefers, Zoe, et al.
Publicado: (2022)

SIRT1 Protects the Heart from ER Stress-Induced Injury by Promoting eEF2K/eEF2-Dependent Autophagy
por: Pires Da Silva, Julie, et al.
Publicado: (2020)

Ghrelin rapidly elevates protein synthesis in vitro by employing the rpS6K-eEF2K-eEF2 signalling axis
por: Zhdanov, Alexander V., et al.
Publicado: (2022)

Characterisation of Translation Elongation Factor eEF1B Subunit Expression in Mammalian Cells and Tissues and Co-Localisation with eEF1A2
por: Cao, Yuan, et al.
Publicado: (2014)

Electroacupuncture Improves Synaptic Function in SAMP8 Mice Probably via Inhibition of the AMPK/eEF2K/eEF2 Signaling Pathway
por: Dong, Weiguo, et al.
Publicado: (2019)

A functional eEF2K-eEF2 pathway in the NAc is critical for the expression of cocaine-induced psychomotor sensitisation and conditioned place preference
por: Beiser, Tehila, et al.
Publicado: (2022)

High eEF1A1 Protein Levels Mark Aggressive Prostate Cancers and the In Vitro Targeting of eEF1A1 Reveals the eEF1A1–actin Complex as a New Potential Target for Therapy
por: Bosutti, Alessandra, et al.
Publicado: (2022)

Ribosome profiling analysis of eEF3-depleted Saccharomyces cerevisiae
por: Kasari, Villu, et al.
Publicado: (2019)

Ribosomal stress activates eEF2K–eEF2 pathway causing translation elongation inhibition and recruitment of Terminal Oligopyrimidine (TOP) mRNAs on polysomes
por: Gismondi, Angelo, et al.
Publicado: (2014)

Inhibition of ER stress-mediated apoptosis in macrophages by nuclear-cytoplasmic relocalization of eEF1A by the HIV-1 Nef protein
por: Abbas, W, et al.
Publicado: (2012)

Inhibition of ER stress-mediated apoptosis in macrophages by nuclear-cytoplasmic relocalization of eEF1A by the HIV-1 Nef protein
por: Abbas, W, et al.
Publicado: (2012)

Structural Models of Human eEF1A1 and eEF1A2 Reveal Two Distinct Surface Clusters of Sequence Variation and Potential Differences in Phosphorylation
por: Soares, Dinesh C., et al.
Publicado: (2009)

Dimethylation of eEF1A at Lysine 55 Plays a Key Role in the Regulation of eEF1A2 on Malignant Cell Functions of Acute Myeloid Leukemia
por: Xiao, Shan, et al.
Publicado: (2020)

The eEF1A Proteins: At the Crossroads of Oncogenesis, Apoptosis, and Viral Infections
por: Abbas, Wasim, et al.
Publicado: (2015)

Eukaryotic Elongation Factor 2 Kinase (eEF2K) in Cancer
por: Wang, Xuemin, et al.
Publicado: (2017)

Highly homologous eEF1A1 and eEF1A2 exhibit differential post-translational modification with significant enrichment around localised sites of sequence variation
por: Soares, Dinesh C, et al.
Publicado: (2013)

The alphavirus nonstructural protein 2 NTPase induces a host translational shut-off through phosphorylation of eEF2 via cAMP-PKA-eEF2K signaling
por: Treffers, Emmely E., et al.
Publicado: (2023)

Post-Training Dephosphorylation of eEF-2 Promotes Protein Synthesis for Memory Consolidation
por: Im, Heh-In, et al.
Publicado: (2009)

The role of protein elongation factor eEF1A2 in ovarian cancer
por: Lee, Jonathan M
Publicado: (2003)

eEF1A Is an S-RNase Binding Factor in Self-Incompatible Solanum chacoense
por: Soulard, Jonathan, et al.
Publicado: (2014)

A conserved PUF/Ago/eEF1A complex attenuates translation elongation
por: Friend, Kyle, et al.
Publicado: (2012)

Ethanolamine phosphoglycerol attachment to eEF1A is not essential for normal growth of Trypanosoma brucei
por: Greganova, Eva, et al.
Publicado: (2012)

MLIF Modulates Microglia Polarization in Ischemic Stroke by Targeting eEF1A1
por: Liu, Yulan, et al.
Publicado: (2021)

Analysis of eEF1A2 gene expression and copy number in cervical carcinoma
por: Zheng, Weinan, et al.
Publicado: (2023)

eEF2K Inhibitor Design: The Progression of Exemplary Structure-Based Drug Design
por: Klupt, Kody A., et al.
Publicado: (2023)

Expression of eEF1A2 is associated with clear cell histology in ovarian carcinomas: overexpression of the gene is not dependent on modifications at the EEF1A2 locus
por: Tomlinson, V A L, et al.
Publicado: (2007)

Novel activity of eukaryotic translocase, eEF2: dissociation of the 80S ribosome into subunits with ATP but not with GTP
por: Demeshkina, Natalia, et al.
Publicado: (2007)

Novel activity of eukaryotic translocase, eEF2: dissociation of the 80S ribosome into subunits with ATP but not with GTP
por: Demeshkina, Natalia, et al.
Publicado: (2007)

The eEF1γ Subunit Contacts RNA Polymerase II and Binds Vimentin Promoter Region
por: Corbi, Nicoletta, et al.
Publicado: (2010)

Evidence for a Negative Cooperativity between eIF5A and eEF2 on Binding to the Ribosome
por: Rossi, Danuza, et al.
Publicado: (2016)

eEF1Bγ binds the Che-1 and TP53 gene promoters and their transcripts
por: Pisani, Cinzia, et al.
Publicado: (2016)

Collaboration of tRNA modifications and elongation factor eEF1A in decoding and nonsense suppression
por: Klassen, Roland, et al.
Publicado: (2018)

AMPK activation, eEF2 inactivation, and reduced protein synthesis in the cerebral cortex of hibernating chipmunks
por: Yamada, Shintaro, et al.
Publicado: (2019)

Yeast translation elongation factor eEF3 promotes late stages of tRNA translocation
por: Ranjan, Namit, et al.
Publicado: (2021)

Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance
por: Smith, Patrick R., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_puvchslrd0fid9iqe6oshpkj0v