Cargando…

Heparanase activates the syndecan-syntenin-ALIX exosome pathway

Exosomes are secreted vesicles of endosomal origin involved in signaling processes. We recently showed that the syndecan heparan sulfate proteoglycans control the biogenesis of exosomes through their interaction with syntenin-1 and the endosomal-sorting complex required for transport accessory compo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Roucourt, Bart, Meeussen, Sofie, Bao, Jie, Zimmermann, Pascale, David, Guido
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387558/ https://www.ncbi.nlm.nih.gov/pubmed/25732677 http://dx.doi.org/10.1038/cr.2015.29

Ejemplares similares

The Flemmingsome reveals an ESCRT-to-membrane coupling via ALIX/syntenin/syndecan-4 required for completion of cytokinesis
por: Addi, Cyril, et al.
Publicado: (2020)

Syntenin-knock out reduces exosome turnover and viral transduction
por: Kashyap, Rudra, et al.
Publicado: (2021)

Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles
por: Cone, Allaura S., et al.
Publicado: (2020)

Syntenin controls migration, growth, proliferation, and cell cycle progression in cancer cells
por: Kashyap, Rudra, et al.
Publicado: (2015)

Syntenin: Key player in cancer exosome biogenesis and uptake?
por: Fares, Joanna, et al.
Publicado: (2016)

Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loading with syndecan and EpCAM cargo
por: Leblanc, R., et al.
Publicado: (2020)

Syntenin mediates SRC function in exosomal cell-to-cell communication
por: Imjeti, Naga Sailaja, et al.
Publicado: (2017)

Effects of syndecan-1 on the expression of syntenin and the migration of U251 glioma cells
por: Chen, Jun, et al.
Publicado: (2017)

Heparanase Regulates Levels of Syndecan-1 in the Nucleus
por: Chen, Ligong, et al.
Publicado: (2009)

New structural insight of C-terminal region of Syntenin-1, enhancing the molecular dimerization and inhibitory function related on Syndecan-4 signaling
por: Choi, Youngsil, et al.
Publicado: (2016)

ALIX- and ESCRT-III–dependent sorting of tetraspanins to exosomes
por: Larios, Jorge, et al.
Publicado: (2020)

Syndecan 4 Upregulation on Activated Langerhans Cells Counteracts Langerin Restriction to Facilitate Hepatitis C Virus Transmission
por: Nijmeijer, Bernadien M., et al.
Publicado: (2020)

Downregulation of stromal syntenin sustains AML development
por: Leblanc, Raphael, et al.
Publicado: (2023)

Immunohistochemical Expression of Heparanase Isoforms and Syndecan-1 Proteins in Colorectal Adenomas
por: Waisberg, J., et al.
Publicado: (2016)

Loss of Syndecan‐1 and Increased Expression of Heparanase in Invasive Esophageal Carcinomas
por: Mikami, Shuji, et al.
Publicado: (2001)

Heparanase and Syndecan-4 Are Involved in Low Molecular Weight Fucoidan-Induced Angiogenesis
por: Haddad, Oualid, et al.
Publicado: (2015)

Role of Heparanase and Syndecan-1 in HSV-1 Release from Infected Cells
por: Sharma, Pankaj, et al.
Publicado: (2022)

Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin
por: Ma, Peisong, et al.
Publicado: (2006)

Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin
por: Ma, Peisong, et al.
Publicado: (2011)

Role of heparanase in ARDS through autophagy and exosome pathway (review)
por: Feng, Fei, et al.
Publicado: (2023)

Anaplasma phagocytophilum Ats-1 enhances exosome secretion through Syntenin-1
por: Li, Ruirui, et al.
Publicado: (2023)

Plasma-Derived Exosomal ALIX as a Novel Biomarker for Diagnosis and Classification of Pancreatic Cancer
por: Yang, Jie, et al.
Publicado: (2021)

Heparanase overexpression down-regulates syndecan-1 expression in a gallbladder carcinoma cell line
por: Jin, Hao, et al.
Publicado: (2017)

The Multifunctional Protein Syntenin-1: Regulator of Exosome Biogenesis, Cellular Function, and Tumor Progression
por: Lee, Kwang-Min, et al.
Publicado: (2023)

High glucose-induced intestinal epithelial barrier damage is aggravated by syndecan-1 destruction and heparanase overexpression
por: Qing, Qing, et al.
Publicado: (2015)

Protease, Growth Factor, and Heparanase-Mediated Syndecan-1 Shedding Leads to Enhanced HSV-1 Egress
por: Karasneh, Ghadah A., et al.
Publicado: (2021)

Syntenin regulates melanogenesis via the p38 MAPK pathway
por: Sun, Lijun, et al.
Publicado: (2020)

Syntenin: PDZ Protein Regulating Signaling Pathways and Cellular Functions
por: Shimada, Tadayuki, et al.
Publicado: (2019)

A positive feedback loop of heparanase/syndecan1/nerve growth factor regulates cancer pain progression
por: Su, Xiaohu, et al.
Publicado: (2023)

Alix is required for activity-dependent bulk endocytosis at brain synapses
por: Laporte, Marine H., et al.
Publicado: (2022)

Proteomic peptide phage display uncovers novel interactions of the PDZ1‐2 supramodule of syntenin
por: Garrido‐Urbani, Sarah, et al.
Publicado: (2016)

Mammalian heparanase: what is the message?
por: Vreys, Veronique, et al.
Publicado: (2007)

Heparanase-induced shedding of syndecan-1/CD138 in myeloma and endothelial cells activates VEGFR2 and an invasive phenotype: prevention by novel synstatins
por: Jung, O, et al.
Publicado: (2016)

Distinct functions of dimeric and monomeric scaffold protein Alix in regulating F-actin assembly and loading of exosomal cargo
por: Qiu, Xiaohui, et al.
Publicado: (2022)

Heparanase Promotes Syndecan-1 Expression to Mediate Fibrillar Collagen and Mammographic Density in Human Breast Tissue Cultured ex vivo
por: Huang, Xuan, et al.
Publicado: (2020)

Frizzled 7 and PIP(2) binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling
por: Egea-Jimenez, Antonio Luis, et al.
Publicado: (2016)

Abrogating ALIX Interactions Results in Stuttering of the ESCRT Machinery
por: Gupta, Shilpa, et al.
Publicado: (2020)

Alix: A Candidate Serum Biomarker of Alzheimer’s Disease
por: Sun, Yingni, et al.
Publicado: (2021)

Syntenin is involved in the bacteria clearance response of kuruma shrimp (Marsupenaeus japonicus)
por: Liu, Qian, et al.
Publicado: (2015)

Syndecan-1-Dependent Regulation of Heparanase Affects Invasiveness, Stem Cell Properties, and Therapeutic Resistance of Caco2 Colon Cancer Cells
por: Katakam, Sampath Kumar, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ti61d6jnv5qk1ovd2o3bs06m72