Y(682)G Mutation of Amyloid Precursor Protein Promotes Endo-Lysosomal Dysfunction by Disrupting APP–SorLA Interaction

The intracellular transport and localization of amyloid precursor protein (APP) are critical determinants of APP processing and β-amyloid peptide production, thus crucially important for the pathophysiology of Alzheimer’s disease (AD). Notably, the C-terminal Y(682)ENPTY(687) domain of APP binds to...

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Detalles Bibliográficos
Autores principales: La Rosa, Luca Rosario, Perrone, Lorena, Nielsen, Morten Schallburg, Calissano, Pietro, Andersen, Olav Michael, Matrone, Carmela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388009/
https://www.ncbi.nlm.nih.gov/pubmed/25904844
http://dx.doi.org/10.3389/fncel.2015.00109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388009/
https://www.ncbi.nlm.nih.gov/pubmed/25904844
http://dx.doi.org/10.3389/fncel.2015.00109

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