SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites

SUMOylation plays important roles in the DNA damage response. However, whether it is important for interstrand crosslink repair remains unknown. We report that the SLX4 nuclease scaffold protein is regulated by SUMOylation. We have identified three SUMO interaction motifs (SIMs) in SLX4, mutating al...

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Detalles Bibliográficos
Autores principales: González-Prieto, Román, Cuijpers, Sabine AG, Luijsterburg, Martijn S, van Attikum, Haico, Vertegaal, Alfred CO
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Scientific Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388617/
https://www.ncbi.nlm.nih.gov/pubmed/25722289
http://dx.doi.org/10.15252/embr.201440017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388617/
https://www.ncbi.nlm.nih.gov/pubmed/25722289
http://dx.doi.org/10.15252/embr.201440017

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