Cargando…

SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites

SUMOylation plays important roles in the DNA damage response. However, whether it is important for interstrand crosslink repair remains unknown. We report that the SLX4 nuclease scaffold protein is regulated by SUMOylation. We have identified three SUMO interaction motifs (SIMs) in SLX4, mutating al...

Descripción completa

Detalles Bibliográficos
Autores principales:	González-Prieto, Román, Cuijpers, Sabine AG, Luijsterburg, Martijn S, van Attikum, Haico, Vertegaal, Alfred CO
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Scientific Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388617/ https://www.ncbi.nlm.nih.gov/pubmed/25722289 http://dx.doi.org/10.15252/embr.201440017

Ejemplares similares

Remodeling and spacing factor 1 (RSF1) deposits centromere proteins at DNA double-strand breaks to promote non-homologous end-joining
por: Helfricht, Angela, et al.
Publicado: (2013)

Mapping the SUMOylated landscape
por: Eifler, Karolin, et al.
Publicado: (2015)

WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks
por: Caron, Pierre, et al.
Publicado: (2019)

ERCC1 mutations impede DNA damage repair and cause liver and kidney dysfunction in patients
por: Apelt, Katja, et al.
Publicado: (2020)

PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining
por: Luijsterburg, Martijn S., et al.
Publicado: (2016)

DDB2 promotes chromatin decondensation at UV-induced DNA damage
por: Luijsterburg, Martijn S., et al.
Publicado: (2012)

Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies
por: Sha, Zhe, et al.
Publicado: (2019)

Functions of PARylation in DNA Damage Repair Pathways
por: Wei, Huiting, et al.
Publicado: (2016)

The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II
por: van der Weegen, Yana, et al.
Publicado: (2020)

PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL
por: Horigome, Chihiro, et al.
Publicado: (2016)

Publisher Correction: The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II
por: van der Weegen, Yana, et al.
Publicado: (2020)

Structural and Mechanistic Analysis of the Slx1-Slx4 Endonuclease
por: Gaur, Vineet, et al.
Publicado: (2015)

CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks
por: Rother, Magdalena B., et al.
Publicado: (2020)

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery
por: Kumar, Ramesh, et al.
Publicado: (2017)

Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets
por: Krastev, Dragomir B., et al.
Publicado: (2018)

SUMO in the DNA damage response
por: Hendriks, Ivo A., et al.
Publicado: (2015)

Uncovering Global SUMOylation Signaling Networks in a Site-Specific Manner
por: Hendriks, Ivo A., et al.
Publicado: (2014)

Antisense oligonucleotide-mediated exon skipping as a strategy to reduce proteolytic cleavage of ataxin-3
por: Toonen, Lodewijk J. A., et al.
Publicado: (2016)

Slx5/Slx8‐dependent ubiquitin hotspots on chromatin contribute to stress tolerance
por: Höpfler, Markus, et al.
Publicado: (2019)

The cross-talk between PARylation and SUMOylation in C/EBPβ at K134 site participates in pathological cardiac hypertrophy
por: Wang, Luping, et al.
Publicado: (2022)

SENP6 regulates localization and nuclear condensation of DNA damage response proteins by group deSUMOylation
por: Claessens, Laura A., et al.
Publicado: (2023)

Crystal structure and SUMO binding of Slx1-Slx4 complex
por: Lian, Fu-Ming, et al.
Publicado: (2016)

Dimerization of SLX4 contributes to functioning of the SLX4-nuclease complex
por: Yin, Jinhu, et al.
Publicado: (2016)

SUMOylation and the HSF1-Regulated Chaperone Network Converge to Promote Proteostasis in Response to Heat Shock
por: Liebelt, Frauke, et al.
Publicado: (2019)

Recognition and processing of branched DNA substrates by Slx1–Slx4 nuclease
por: Gaur, Vineet, et al.
Publicado: (2019)

Structure specific DNA recognition by the SLX1–SLX4 endonuclease complex
por: Xu, Xiang, et al.
Publicado: (2021)

XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair
por: Blessing, Charlotte, et al.
Publicado: (2022)

Targeting dePARylation for cancer therapy
por: Kassab, Muzaffer Ahmad, et al.
Publicado: (2020)

The CHD6 chromatin remodeler is an oxidative DNA damage response factor
por: Moore, Shaun, et al.
Publicado: (2019)

Activation of the DNA Damage Response Is a Conserved Function of HIV-1 and HIV-2 Vpr That Is Independent of SLX4 Recruitment
por: Fregoso, Oliver I., et al.
Publicado: (2016)

Slx8 Removes Pli1-Dependent Protein-SUMO Conjugates Including SUMOylated Topoisomerase I to Promote Genome Stability
por: Steinacher, Roland, et al.
Publicado: (2013)

DNA-PKcs PARylation regulates DNA-PK kinase activity in the DNA damage response
por: Han, Yang, et al.
Publicado: (2019)

Molecular mechanisms of APC/C release from spindle assembly checkpoint inhibition by APC/C SUMOylation
por: Yatskevich, Stanislau, et al.
Publicado: (2021)

PARP-mediated PARylation of MGMT is critical to promote repair of temozolomide-induced O(6)-methylguanine DNA damage in glioblastoma
por: Wu, Shaofang, et al.
Publicado: (2021)

Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair
por: Klement, Karolin, et al.
Publicado: (2014)

PARP Inhibitors as Therapeutics: Beyond Modulation of PARylation
por: Min, Ahrum, et al.
Publicado: (2020)

SPINDOC binds PARP1 to facilitate PARylation
por: Yang, Fen, et al.
Publicado: (2021)

NAMPT and PARylation Are Involved in the Pathogenesis of Atopic Dermatitis
por: Arroyo, Ana B., et al.
Publicado: (2023)

SUMOylation Is Associated with Aggressive Behavior in Chondrosarcoma of Bone
por: Kroonen, Jessie S., et al.
Publicado: (2021)

Purification of the yeast Slx5–Slx8 protein complex and characterization of its DNA-binding activity
por: Yang, Litao, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_k48o2nqvqfiek7olsfkh49h5no