Stepwise Catalytic Mechanism via Short-Lived Intermediate Inferred from Combined QM/MM MERP and PES Calculations on Retaining Glycosyltransferase ppGalNAcT2

The glycosylation of cell surface proteins plays a crucial role in a multitude of biological processes, such as cell adhesion and recognition. To understand the process of protein glycosylation, the reaction mechanisms of the participating enzymes need to be known. However, the reaction mechanism of...

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Detalles Bibliográficos
Autores principales: Trnka, Tomáš, Kozmon, Stanislav, Tvaroška, Igor, Koča, Jaroslav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388629/
https://www.ncbi.nlm.nih.gov/pubmed/25849117
http://dx.doi.org/10.1371/journal.pcbi.1004061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388629/
https://www.ncbi.nlm.nih.gov/pubmed/25849117
http://dx.doi.org/10.1371/journal.pcbi.1004061

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