Post-PKS Tailoring Steps of a Disaccharide-Containing Polyene NPP in Pseudonocardia autotrophica

A novel polyene compound NPP identified in a rare actinomycetes, Pseudonocardia autotrophica KCTC9441, was shown to contain an aglycone identical to nystatin but to harbor a unique di-sugar moiety, mycosaminyl-(α1-4)-N-acetyl-glucosamine, which led to higher solubility and reduced hemolytic activity...

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Detalles Bibliográficos
Autores principales: Kim, Hye-Jin, Kim, Min-Kyung, Lee, Mi-Jin, Won, Hyung-Jin, Choi, Si-Sun, Kim, Eung-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388683/
https://www.ncbi.nlm.nih.gov/pubmed/25849545
http://dx.doi.org/10.1371/journal.pone.0123270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388683/
https://www.ncbi.nlm.nih.gov/pubmed/25849545
http://dx.doi.org/10.1371/journal.pone.0123270

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