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Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss

Immunglobulin G (IgG) sialylation represents a key checkpoint that determines the engagement of pro- or anti-inflammatory Fcγ receptors (FcγR) and the direction of the immune response. Whether IgG sialylation influences osteoclast differentiation and subsequently bone architecture has not been deter...

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Detalles Bibliográficos
Autores principales: Harre, Ulrike, Lang, Stefanie C., Pfeifle, René, Rombouts, Yoann, Frühbeißer, Sabine, Amara, Khaled, Bang, Holger, Lux, Anja, Koeleman, Carolien A., Baum, Wolfgang, Dietel, Katharina, Gröhn, Franziska, Malmström, Vivianne, Klareskog, Lars, Krönke, Gerhard, Kocijan, Roland, Nimmerjahn, Falk, Toes, René E. M., Herrmann, Martin, Scherer, Hans Ulrich, Schett, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389255/
https://www.ncbi.nlm.nih.gov/pubmed/25825024
http://dx.doi.org/10.1038/ncomms7651