Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase

The polyketide natural product borrelidin displays antibacterial, antifungal, antimalarial, anticancer, insecticidal and herbicidal activities through the selective inhibition of threonyl-tRNA synthetase (ThrRS). How borrelidin simultaneously attenuates bacterial growth and suppresses a variety of i...

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Detalles Bibliográficos
Autores principales: Fang, Pengfei, Yu, Xue, Jeong, Seung Jae, Mirando, Adam, Chen, Kaige, Chen, Xin, Kim, Sunghoon, Francklyn, Christopher S., Guo, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389257/
https://www.ncbi.nlm.nih.gov/pubmed/25824639
http://dx.doi.org/10.1038/ncomms7402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389257/
https://www.ncbi.nlm.nih.gov/pubmed/25824639
http://dx.doi.org/10.1038/ncomms7402

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