Short-term inhibition of 11β-hydroxysteroid dehydrogenase type 1 reversibly improves spatial memory but persistently impairs contextual fear memory in aged mice

High glucocorticoid levels induced by stress enhance the memory of fearful events and may contribute to the development of anxiety and posttraumatic stress disorder. In contrast, elevated glucocorticoids associated with ageing impair spatial memory. We have previously shown that pharmacological inhi...

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Detalles Bibliográficos
Autores principales: Wheelan, Nicola, Webster, Scott P., Kenyon, Christopher J., Caughey, Sarah, Walker, Brian R., Holmes, Megan C., Seckl, Jonathan R., Yau, Joyce L.W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389269/
https://www.ncbi.nlm.nih.gov/pubmed/25497454
http://dx.doi.org/10.1016/j.neuropharm.2014.12.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389269/
https://www.ncbi.nlm.nih.gov/pubmed/25497454
http://dx.doi.org/10.1016/j.neuropharm.2014.12.005

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