Elementary properties of Ca(2+) channels and their influence on multivesicular release and phase-locking at auditory hair cell ribbon synapses

Voltage-gated calcium (Ca(v)1.3) channels in mammalian inner hair cells (IHCs) open in response to sound and the resulting Ca(2+) entry triggers the release of the neurotransmitter glutamate onto afferent terminals. At low to mid sound frequencies cell depolarization follows the sound sinusoid and p...

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Autores principales: Magistretti, Jacopo, Spaiardi, Paolo, Johnson, Stuart L., Masetto, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389406/
https://www.ncbi.nlm.nih.gov/pubmed/25904847
http://dx.doi.org/10.3389/fncel.2015.00123
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author Magistretti, Jacopo
Spaiardi, Paolo
Johnson, Stuart L.
Masetto, Sergio
author_facet Magistretti, Jacopo
Spaiardi, Paolo
Johnson, Stuart L.
Masetto, Sergio
author_sort Magistretti, Jacopo
collection PubMed
description Voltage-gated calcium (Ca(v)1.3) channels in mammalian inner hair cells (IHCs) open in response to sound and the resulting Ca(2+) entry triggers the release of the neurotransmitter glutamate onto afferent terminals. At low to mid sound frequencies cell depolarization follows the sound sinusoid and pulses of transmitter release from the hair cell generate excitatory postsynaptic currents (EPSCs) in the afferent fiber that translate into a phase-locked pattern of action potential activity. The present article summarizes our current understanding on the elementary properties of single IHC Ca(2+) channels, and how these could have functional implications for certain, poorly understood, features of synaptic transmission at auditory hair cell ribbon synapses.
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spelling pubmed-43894062015-04-22 Elementary properties of Ca(2+) channels and their influence on multivesicular release and phase-locking at auditory hair cell ribbon synapses Magistretti, Jacopo Spaiardi, Paolo Johnson, Stuart L. Masetto, Sergio Front Cell Neurosci Neuroscience Voltage-gated calcium (Ca(v)1.3) channels in mammalian inner hair cells (IHCs) open in response to sound and the resulting Ca(2+) entry triggers the release of the neurotransmitter glutamate onto afferent terminals. At low to mid sound frequencies cell depolarization follows the sound sinusoid and pulses of transmitter release from the hair cell generate excitatory postsynaptic currents (EPSCs) in the afferent fiber that translate into a phase-locked pattern of action potential activity. The present article summarizes our current understanding on the elementary properties of single IHC Ca(2+) channels, and how these could have functional implications for certain, poorly understood, features of synaptic transmission at auditory hair cell ribbon synapses. Frontiers Media S.A. 2015-04-08 /pmc/articles/PMC4389406/ /pubmed/25904847 http://dx.doi.org/10.3389/fncel.2015.00123 Text en Copyright © 2015 Magistretti, Spaiardi, Johnson and Masetto. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Magistretti, Jacopo
Spaiardi, Paolo
Johnson, Stuart L.
Masetto, Sergio
Elementary properties of Ca(2+) channels and their influence on multivesicular release and phase-locking at auditory hair cell ribbon synapses
title Elementary properties of Ca(2+) channels and their influence on multivesicular release and phase-locking at auditory hair cell ribbon synapses
title_full Elementary properties of Ca(2+) channels and their influence on multivesicular release and phase-locking at auditory hair cell ribbon synapses
title_fullStr Elementary properties of Ca(2+) channels and their influence on multivesicular release and phase-locking at auditory hair cell ribbon synapses
title_full_unstemmed Elementary properties of Ca(2+) channels and their influence on multivesicular release and phase-locking at auditory hair cell ribbon synapses
title_short Elementary properties of Ca(2+) channels and their influence on multivesicular release and phase-locking at auditory hair cell ribbon synapses
title_sort elementary properties of ca(2+) channels and their influence on multivesicular release and phase-locking at auditory hair cell ribbon synapses
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389406/
https://www.ncbi.nlm.nih.gov/pubmed/25904847
http://dx.doi.org/10.3389/fncel.2015.00123
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