KCa3.1/IK1 Channel Regulation by cGMP-Dependent Protein Kinase (PKG) via Reactive Oxygen Species and CaMKII in Microglia: An Immune Modulating Feedback System?

The intermediate conductance Ca(2+)-activated K(+) channel, KCa3.1 (IK1/SK4/KCNN4) is widely expressed in the innate and adaptive immune system. KCa3.1 contributes to proliferation of activated T lymphocytes, and in CNS-resident microglia, it contributes to Ca(2+) signaling, migration, and productio...

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Detalles Bibliográficos
Autores principales: Ferreira, Roger, Wong, Raymond, Schlichter, Lyanne C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389654/
https://www.ncbi.nlm.nih.gov/pubmed/25904916
http://dx.doi.org/10.3389/fimmu.2015.00153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389654/
https://www.ncbi.nlm.nih.gov/pubmed/25904916
http://dx.doi.org/10.3389/fimmu.2015.00153

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