Mutations in the PCNA-binding site of CDKN1C inhibit cell proliferation by impairing the entry into S phase

CDKN1C (also known as P57(kip2)) is a cyclin-dependent kinase inhibitor that functions as a negative regulator of cell proliferation through G1 phase cell cycle arrest. Recently, our group described gain-of-function mutations in the PCNA-binding site of CDKN1C that result in an undergrowth syndrome...

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Detalles Bibliográficos
Autores principales: Borges, Kleiton S, Arboleda, Valerie A, Vilain, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389716/
https://www.ncbi.nlm.nih.gov/pubmed/25861374
http://dx.doi.org/10.1186/s13008-015-0008-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389716/
https://www.ncbi.nlm.nih.gov/pubmed/25861374
http://dx.doi.org/10.1186/s13008-015-0008-8

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