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Mutations in the PCNA-binding site of CDKN1C inhibit cell proliferation by impairing the entry into S phase
CDKN1C (also known as P57(kip2)) is a cyclin-dependent kinase inhibitor that functions as a negative regulator of cell proliferation through G1 phase cell cycle arrest. Recently, our group described gain-of-function mutations in the PCNA-binding site of CDKN1C that result in an undergrowth syndrome...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389716/ https://www.ncbi.nlm.nih.gov/pubmed/25861374 http://dx.doi.org/10.1186/s13008-015-0008-8 |