Cellular responses to a prolonged delay in mitosis are determined by a DNA damage response controlled by Bcl-2 family proteins

Anti-cancer drugs that disrupt mitosis inhibit cell proliferation and induce apoptosis, although the mechanisms of these responses are poorly understood. Here, we characterize a mitotic stress response that determines cell fate in response to microtubule poisons. We show that mitotic arrest induced...

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Detalles Bibliográficos
Autores principales: Colin, Didier J., Hain, Karolina O., Allan, Lindsey A., Clarke, Paul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389791/
https://www.ncbi.nlm.nih.gov/pubmed/25761368
http://dx.doi.org/10.1098/rsob.140156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389791/
https://www.ncbi.nlm.nih.gov/pubmed/25761368
http://dx.doi.org/10.1098/rsob.140156

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