Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo

Cigarette smoking promotes body weight reduction in humans while paradoxically also promoting insulin resistance (IR) and hyperinsulinemia. The mechanisms behind these effects of smoking are unclear. Here, we show that nicotine, a major constitute of cigarette smoke, selectively activates AMP-activa...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Yue, Song, Ping, Zhang, Wencheng, Liu, Junhui, Dai, Xiaoyan, Liu, Zhaoyu, Lu, Qiulun, Ouyang, Changhan, Xie, Zhonglin, Zhao, Zhengxing, Zhuo, Xiaozhen, Viollet, Benoit, Foretz, Marc, Wu, Jiliang, Yuan, Zuyi, Zou, Ming-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390501/
https://www.ncbi.nlm.nih.gov/pubmed/25799226
http://dx.doi.org/10.1038/nm.3826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390501/
https://www.ncbi.nlm.nih.gov/pubmed/25799226
http://dx.doi.org/10.1038/nm.3826

Ejemplares similares