A reliable method for the detection of BRCA1 and BRCA2 mutations in fixed tumour tissue utilising multiplex PCR-based targeted next generation sequencing

BACKGROUND: Germline mutations in BRCA1 or BRCA2 lead to a high lifetime probability of developing ovarian or breast cancer. These genes can also be involved in the development of non-hereditary tumours as somatic BRCA1/2 pathogenic variants are found in some of these cancers. Since patients with so...

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Detalles Bibliográficos
Autores principales: Ellison, Gillian, Huang, Shuwen, Carr, Hedley, Wallace, Andrew, Ahdesmaki, Miika, Bhaskar, Sanjeev, Mills, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391122/
https://www.ncbi.nlm.nih.gov/pubmed/25859162
http://dx.doi.org/10.1186/s12907-015-0004-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391122/
https://www.ncbi.nlm.nih.gov/pubmed/25859162
http://dx.doi.org/10.1186/s12907-015-0004-6

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