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Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABA(A) receptor α4 subunit
Despite numerous advances, treatment-resistant seizures remain an important problem. Loss of neuronal inhibition is present in a variety of epilepsy models and is suggested as a mechanism for increased excitability, leading to the proposal that grafting inhibitory interneurons into seizure foci migh...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391265/ https://www.ncbi.nlm.nih.gov/pubmed/25914623 http://dx.doi.org/10.3389/fncel.2015.00127 |