Limited Effects of an eIF2α (S51A) Allele on Neurological Impairments in the 5xFAD Mouse Model of Alzheimer's Disease

Alzheimer's disease (AD) has been associated with increased phosphorylation of the translation initiation factor 2α (eIF2α) at serine 51. Increased phosphorylation of eIF2α alters translational control and may thereby have adverse effects on synaptic plasticity, learning, and memory. To analyze...

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Detalles Bibliográficos
Autores principales: Paesler, Katharina, Xie, Kan, Hettich, Moritz M., Siwek, Magdalena E., Ryan, Devon P., Schröder, Susanne, Papazoglou, Anna, Broich, Karl, Müller, Ralf, Trog, Astrid, Garthe, Alexander, Kempermann, Gerd, Weiergräber, Marco, Ehninger, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391319/
https://www.ncbi.nlm.nih.gov/pubmed/25883808
http://dx.doi.org/10.1155/2015/825157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391319/
https://www.ncbi.nlm.nih.gov/pubmed/25883808
http://dx.doi.org/10.1155/2015/825157

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