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Serum concentration of eicosapentaenoic acid is associated with cognitive function in patients with coronary artery disease

BACKGROUND: Recent studies have shown that intake of n-3 polyunsaturated fatty acids (PUFAs) is associated with reduced risk of cognitive impairment and coronary artery disease (CAD); however, it is currently unknown whether reduced serum n-3 PUFA is associated with cognitive impairment in patients...

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Autores principales: Yagi, Shusuke, Hara, Tomoya, Ueno, Rie, Aihara, Ken-ichi, Fukuda, Daiju, Takashima, Akira, Hotchi, Junko, Ise, Takayuki, Yamaguchi, Koji, Tobiume, Takeshi, Iwase, Takashi, Yamada, Hirotsugu, Soeki, Takeshi, Wakatsuki, Tetsuzo, Shimabukuro, Michio, Akaike, Masashi, Sata, Masataka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391466/
https://www.ncbi.nlm.nih.gov/pubmed/25471307
http://dx.doi.org/10.1186/1475-2891-13-112
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author Yagi, Shusuke
Hara, Tomoya
Ueno, Rie
Aihara, Ken-ichi
Fukuda, Daiju
Takashima, Akira
Hotchi, Junko
Ise, Takayuki
Yamaguchi, Koji
Tobiume, Takeshi
Iwase, Takashi
Yamada, Hirotsugu
Soeki, Takeshi
Wakatsuki, Tetsuzo
Shimabukuro, Michio
Akaike, Masashi
Sata, Masataka
author_facet Yagi, Shusuke
Hara, Tomoya
Ueno, Rie
Aihara, Ken-ichi
Fukuda, Daiju
Takashima, Akira
Hotchi, Junko
Ise, Takayuki
Yamaguchi, Koji
Tobiume, Takeshi
Iwase, Takashi
Yamada, Hirotsugu
Soeki, Takeshi
Wakatsuki, Tetsuzo
Shimabukuro, Michio
Akaike, Masashi
Sata, Masataka
author_sort Yagi, Shusuke
collection PubMed
description BACKGROUND: Recent studies have shown that intake of n-3 polyunsaturated fatty acids (PUFAs) is associated with reduced risk of cognitive impairment and coronary artery disease (CAD); however, it is currently unknown whether reduced serum n-3 PUFA is associated with cognitive impairment in patients with CAD. METHODS: We retrospectively evaluated cognitive function with the mini-mental state examination (MMSE), serum levels of PUFAs (including eicosapentaenoic acid [EPA], docosahexaenoic acid [DHA], dihomogammalinolenic acid [DGLA], and arachidonic acid [AA]), cardiovascular risk factors (hypertension, dyslipidemia, diabetes mellitus, cerebrovascular disease, and history of current/previous smoking), and parameters of cardiac function (left ventricular ejection fraction and brain natriuretic peptide levels) in 146 Japanese CAD patients. The associations between the MMSE scores and the other parameters were evaluated. RESULTS: Pearson correlation analysis showed that EPA (R = 0.25, P <0.01), EPA/AA ratio (R = 0.22, P = 0.01), and left ventricular ejection fraction (R = 0.15, P = 0.04) were positively associated with MMSE score, and that age (R = −0.20, P <0.01) and brain natriuretic peptide levels (R = −0.28, P <0.01) were inversely associated with MMSE score. Multiple regression analysis showed that age (P <0.05) was negatively associated with MMSE score, while EPA (P <0.01) and EPA/AA ratio (P <0.05) were positively associated with MMSE score; however, sex; body mass index; left ventricular ejection fraction; levels of DHA, AA, and DGLA; DHA/AA ratio; brain natriuretic peptide; and presence of hypertension, dyslipidemia, diabetes mellitus, cerebrovascular disease, and history of current/previous smoking were statistically excluded. CONCLUSIONS: Serum EPA concentration is associated with cognitive function in patients with CAD, suggesting that a low serum EPA level is a risk factor for cognitive impairment independent of cardiac function, including left ventricular ejection fraction. This correlation potentially lends further support to a role of dietary n-3 PUFAs in preventing the cognitive decline in CAD patients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1475-2891-13-112) contains supplementary material, which is available to authorized users.
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spelling pubmed-43914662015-04-10 Serum concentration of eicosapentaenoic acid is associated with cognitive function in patients with coronary artery disease Yagi, Shusuke Hara, Tomoya Ueno, Rie Aihara, Ken-ichi Fukuda, Daiju Takashima, Akira Hotchi, Junko Ise, Takayuki Yamaguchi, Koji Tobiume, Takeshi Iwase, Takashi Yamada, Hirotsugu Soeki, Takeshi Wakatsuki, Tetsuzo Shimabukuro, Michio Akaike, Masashi Sata, Masataka Nutr J Research BACKGROUND: Recent studies have shown that intake of n-3 polyunsaturated fatty acids (PUFAs) is associated with reduced risk of cognitive impairment and coronary artery disease (CAD); however, it is currently unknown whether reduced serum n-3 PUFA is associated with cognitive impairment in patients with CAD. METHODS: We retrospectively evaluated cognitive function with the mini-mental state examination (MMSE), serum levels of PUFAs (including eicosapentaenoic acid [EPA], docosahexaenoic acid [DHA], dihomogammalinolenic acid [DGLA], and arachidonic acid [AA]), cardiovascular risk factors (hypertension, dyslipidemia, diabetes mellitus, cerebrovascular disease, and history of current/previous smoking), and parameters of cardiac function (left ventricular ejection fraction and brain natriuretic peptide levels) in 146 Japanese CAD patients. The associations between the MMSE scores and the other parameters were evaluated. RESULTS: Pearson correlation analysis showed that EPA (R = 0.25, P <0.01), EPA/AA ratio (R = 0.22, P = 0.01), and left ventricular ejection fraction (R = 0.15, P = 0.04) were positively associated with MMSE score, and that age (R = −0.20, P <0.01) and brain natriuretic peptide levels (R = −0.28, P <0.01) were inversely associated with MMSE score. Multiple regression analysis showed that age (P <0.05) was negatively associated with MMSE score, while EPA (P <0.01) and EPA/AA ratio (P <0.05) were positively associated with MMSE score; however, sex; body mass index; left ventricular ejection fraction; levels of DHA, AA, and DGLA; DHA/AA ratio; brain natriuretic peptide; and presence of hypertension, dyslipidemia, diabetes mellitus, cerebrovascular disease, and history of current/previous smoking were statistically excluded. CONCLUSIONS: Serum EPA concentration is associated with cognitive function in patients with CAD, suggesting that a low serum EPA level is a risk factor for cognitive impairment independent of cardiac function, including left ventricular ejection fraction. This correlation potentially lends further support to a role of dietary n-3 PUFAs in preventing the cognitive decline in CAD patients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1475-2891-13-112) contains supplementary material, which is available to authorized users. BioMed Central 2014-12-04 /pmc/articles/PMC4391466/ /pubmed/25471307 http://dx.doi.org/10.1186/1475-2891-13-112 Text en © Yagi et al.; licensee BioMed Central. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Yagi, Shusuke
Hara, Tomoya
Ueno, Rie
Aihara, Ken-ichi
Fukuda, Daiju
Takashima, Akira
Hotchi, Junko
Ise, Takayuki
Yamaguchi, Koji
Tobiume, Takeshi
Iwase, Takashi
Yamada, Hirotsugu
Soeki, Takeshi
Wakatsuki, Tetsuzo
Shimabukuro, Michio
Akaike, Masashi
Sata, Masataka
Serum concentration of eicosapentaenoic acid is associated with cognitive function in patients with coronary artery disease
title Serum concentration of eicosapentaenoic acid is associated with cognitive function in patients with coronary artery disease
title_full Serum concentration of eicosapentaenoic acid is associated with cognitive function in patients with coronary artery disease
title_fullStr Serum concentration of eicosapentaenoic acid is associated with cognitive function in patients with coronary artery disease
title_full_unstemmed Serum concentration of eicosapentaenoic acid is associated with cognitive function in patients with coronary artery disease
title_short Serum concentration of eicosapentaenoic acid is associated with cognitive function in patients with coronary artery disease
title_sort serum concentration of eicosapentaenoic acid is associated with cognitive function in patients with coronary artery disease
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391466/
https://www.ncbi.nlm.nih.gov/pubmed/25471307
http://dx.doi.org/10.1186/1475-2891-13-112
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