DHFR-mediated effects of methotrexate in medulloblastoma and osteosarcoma cells: The same outcome of treatment with different doses in sensitive cell lines

Although methotrexate (MTX) is the most well-known antifolate included in many standard therapeutic regimens, substantial toxicity limits its wider use, particularly in pediatric oncology. Our study focused on a detailed analysis of MTX effects in cell lines derived from two types of pediatric solid...

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Detalles Bibliográficos
Autores principales: NERADIL, JAKUB, PAVLASOVA, GABRIELA, SRAMEK, MARTIN, KYR, MICHAL, VESELSKA, RENATA, STERBA, JAROSLAV
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391593/
https://www.ncbi.nlm.nih.gov/pubmed/25739012
http://dx.doi.org/10.3892/or.2015.3819

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391593/
https://www.ncbi.nlm.nih.gov/pubmed/25739012
http://dx.doi.org/10.3892/or.2015.3819

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