In Vitro Microtumors Provide a Physiologically Predictive Tool for Breast Cancer Therapeutic Screening

Many anti-cancer drugs fail in human trials despite showing efficacy in preclinical models. It is clear that the in vitro assays involving 2D monoculture do not reflect the complex extracellular matrix, chemical, and cellular microenvironment of the tumor tissue, and this may explain the failure of...

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Detalles Bibliográficos
Autores principales: Benton, Gabriel, DeGray, Gerald, Kleinman, Hynda K., George, Jay, Arnaoutova, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391795/
https://www.ncbi.nlm.nih.gov/pubmed/25856378
http://dx.doi.org/10.1371/journal.pone.0123312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391795/
https://www.ncbi.nlm.nih.gov/pubmed/25856378
http://dx.doi.org/10.1371/journal.pone.0123312

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