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In Vitro Microtumors Provide a Physiologically Predictive Tool for Breast Cancer Therapeutic Screening
Many anti-cancer drugs fail in human trials despite showing efficacy in preclinical models. It is clear that the in vitro assays involving 2D monoculture do not reflect the complex extracellular matrix, chemical, and cellular microenvironment of the tumor tissue, and this may explain the failure of...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391795/ https://www.ncbi.nlm.nih.gov/pubmed/25856378 http://dx.doi.org/10.1371/journal.pone.0123312 |