A microRNA-mediated regulatory loop modulates NOTCH and MYC oncogenic signals in B and T cell malignancies

Growing evidence suggests that microRNAs facilitate the cross-talk between transcriptional modules and signal transduction pathways. MYC and NOTCH1 contribute to the pathogenesis of lymphoid malignancies. NOTCH induces MYC, connecting two signaling programs that enhance oncogenicity. Here we show th...

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Detalles Bibliográficos
Autores principales: Ortega, Manoela, Bhatnagar, Harshita, Lin, An-Ping, Wang, Long, Aster, Jon C, Sill, Heinz, Aguiar, Ricardo C T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391979/
https://www.ncbi.nlm.nih.gov/pubmed/25311243
http://dx.doi.org/10.1038/leu.2014.302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391979/
https://www.ncbi.nlm.nih.gov/pubmed/25311243
http://dx.doi.org/10.1038/leu.2014.302

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