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Expression of xCT and activity of system x(c)(−) are regulated by NRF2 in human breast cancer cells in response to oxidative stress

Cancer cells adapt to high levels of oxidative stress in order to survive and proliferate by activating key transcription factors. One such master regulator, the redox sensitive transcription factor NF E2 Related Factor 2 (NRF2), controls the expression of cellular defense genes including those enco...

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Detalles Bibliográficos
Autores principales: Habib, Eric, Linher-Melville, Katja, Lin, Han-Xin, Singh, Gurmit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392061/
https://www.ncbi.nlm.nih.gov/pubmed/25827424
http://dx.doi.org/10.1016/j.redox.2015.03.003