A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

NAD metabolism regulates diverse biological processes, including ageing, circadian rhythm and axon survival. Axons depend on the activity of the central enzyme in NAD biosynthesis, nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2), for their maintenance and degenerate rapidly when this acti...

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Detalles Bibliográficos
Autores principales: Di Stefano, M, Nascimento-Ferreira, I, Orsomando, G, Mori, V, Gilley, J, Brown, R, Janeckova, L, Vargas, M E, Worrell, L A, Loreto, A, Tickle, J, Patrick, J, Webster, J R M, Marangoni, M, Carpi, F M, Pucciarelli, S, Rossi, F, Meng, W, Sagasti, A, Ribchester, R R, Magni, G, Coleman, M P, Conforti, L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392071/
https://www.ncbi.nlm.nih.gov/pubmed/25323584
http://dx.doi.org/10.1038/cdd.2014.164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392071/
https://www.ncbi.nlm.nih.gov/pubmed/25323584
http://dx.doi.org/10.1038/cdd.2014.164

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