The future of EPAC-targeted therapies: agonism versus antagonism

Pharmaceutical manipulation of cAMP levels exerts beneficial effects through the regulation of the exchange protein activated by cAMP (EPAC) and protein kinase A (PKA) signalling routes. Recent attention has turned to the specific regulation of EPAC isoforms (EPAC1 and EPAC2) as a more targeted appr...

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Detalles Bibliográficos
Autores principales: Parnell, Euan, Palmer, Timothy M., Yarwood, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published By Elsevier In Association With The International Union Of Pharmacology 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392396/
https://www.ncbi.nlm.nih.gov/pubmed/25744542
http://dx.doi.org/10.1016/j.tips.2015.02.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392396/
https://www.ncbi.nlm.nih.gov/pubmed/25744542
http://dx.doi.org/10.1016/j.tips.2015.02.003

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