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Peripheral injury of pelvic visceral sensory nerves alters GFRα (GDNF family receptor alpha) localization in sensory and autonomic pathways of the sacral spinal cord

GDNF (glial cell line-derived neurotrophic factor), neurturin and artemin use their co-receptors (GFRα1, GFRα2 and GFRα3, respectively) and the tyrosine kinase Ret for downstream signaling. In rodent dorsal root ganglia (DRG) most of the unmyelinated and some myelinated sensory afferents express at...

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Detalles Bibliográficos
Autores principales: Forrest, Shelley L., Payne, Sophie C., Keast, Janet R., Osborne, Peregrine B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392586/
https://www.ncbi.nlm.nih.gov/pubmed/25914629
http://dx.doi.org/10.3389/fnana.2015.00043