Repression of Igf1 expression by Ezh2 prevents basal cell differentiation in the developing lung

Epigenetic mechanisms involved in the establishment of lung epithelial cell lineage identities during development are largely unknown. Here, we explored the role of the histone methyltransferase Ezh2 during lung lineage determination. Loss of Ezh2 in the lung epithelium leads to defective lung forma...

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Detalles Bibliográficos
Autores principales: Galvis, Laura A., Holik, Aliaksei Z., Short, Kieran M., Pasquet, Julie, Lun, Aaron T. L., Blewitt, Marnie E., Smyth, Ian M., Ritchie, Matthew E., Asselin-Labat, Marie-Liesse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392602/
https://www.ncbi.nlm.nih.gov/pubmed/25790853
http://dx.doi.org/10.1242/dev.122077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392602/
https://www.ncbi.nlm.nih.gov/pubmed/25790853
http://dx.doi.org/10.1242/dev.122077

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