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Pharmacokinetics of nalbuphine hydrochloride extended release tablets in hemodialysis patients with exploratory effect on pruritus

BACKGROUND: Uremic pruritus is a common and deleterious condition among hemodialysis (HD) patients. Central gating of μ/κ opiate circuitry plays an important role in mediating and countering pruritogenic sensation. The objective of this study was to assess the safety and pharmacokinetics (PK) of the...

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Detalles Bibliográficos
Autores principales:	Hawi, Amale, Alcorn, Harry, Berg, Jolene, Hines, Carey, Hait, Howard, Sciascia, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392787/ https://www.ncbi.nlm.nih.gov/pubmed/25885112 http://dx.doi.org/10.1186/s12882-015-0043-3

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