Sequence analysis reveals a conserved extension in the capping enzyme of the alphavirus supergroup, and a homologous domain in nodaviruses

BACKGROUND: Members of the alphavirus supergroup include human pathogens such as chikungunya virus, hepatitis E virus and rubella virus. They encode a capping enzyme with methyltransferase-guanylyltransferase (MTase-GTase) activity, which is an attractive drug target owing to its unique mechanism. H...

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Detalles Bibliográficos
Autores principales: Ahola, Tero, Karlin, David G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392871/
https://www.ncbi.nlm.nih.gov/pubmed/25886938
http://dx.doi.org/10.1186/s13062-015-0050-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392871/
https://www.ncbi.nlm.nih.gov/pubmed/25886938
http://dx.doi.org/10.1186/s13062-015-0050-0

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