The DNA Helicase Recql4 Is Required for Normal Osteoblast Expansion and Osteosarcoma Formation

RECQL4 mutations are associated with Rothmund Thomson Syndrome (RTS), RAPADILINO Syndrome and Baller-Gerold Syndrome. These patients display a range of benign skeletal abnormalities such as low bone mass. In addition, RTS patients have a highly increased incidence of osteosarcoma (OS). The role of R...

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Detalles Bibliográficos
Autores principales: Ng, Alvin J. M., Walia, Mannu K., Smeets, Monique F., Mutsaers, Anthony J., Sims, Natalie A., Purton, Louise E., Walsh, Nicole C., Martin, T. John, Walkley, Carl R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393104/
https://www.ncbi.nlm.nih.gov/pubmed/25859855
http://dx.doi.org/10.1371/journal.pgen.1005160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393104/
https://www.ncbi.nlm.nih.gov/pubmed/25859855
http://dx.doi.org/10.1371/journal.pgen.1005160

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