Cargando…

The DNA Helicase Recql4 Is Required for Normal Osteoblast Expansion and Osteosarcoma Formation

RECQL4 mutations are associated with Rothmund Thomson Syndrome (RTS), RAPADILINO Syndrome and Baller-Gerold Syndrome. These patients display a range of benign skeletal abnormalities such as low bone mass. In addition, RTS patients have a highly increased incidence of osteosarcoma (OS). The role of R...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ng, Alvin J. M., Walia, Mannu K., Smeets, Monique F., Mutsaers, Anthony J., Sims, Natalie A., Purton, Louise E., Walsh, Nicole C., Martin, T. John, Walkley, Carl R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393104/ https://www.ncbi.nlm.nih.gov/pubmed/25859855 http://dx.doi.org/10.1371/journal.pgen.1005160

Ejemplares similares

ATP-dependent helicase activity is dispensable for the physiological functions of Recql4
por: Castillo-Tandazo, Wilson, et al.
Publicado: (2019)

Genetically engineered mouse models and human osteosarcoma
por: Ng, Alvin JM, et al.
Publicado: (2012)

RECQL: a DNA helicase in breast cancer
por: Akbari, Mohammad R., et al.
Publicado: (2015)

PTHrP, its receptor, and protein kinase A activation in osteosarcoma
por: Walkley, Carl R, et al.
Publicado: (2014)

Tolerance to sustained activation of the cAMP/Creb pathway activity in osteoblastic cells is enabled by loss of p53
por: Walia, Mannu K., et al.
Publicado: (2018)

Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5
por: Newman, Joseph A., et al.
Publicado: (2017)

Distinct prognosis of mRNA expression of the five RecQ DNA-helicase family members – RECQL, BLM, WRN, RECQL4, and RECQL5 – in patients with breast cancer
por: Zhu, Xuan, et al.
Publicado: (2018)

Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance
por: Walia, Mannu K, et al.
Publicado: (2016)

RecQL4 Helicase Amplification Is Involved in Human Breast Tumorigenesis
por: Fang, Hongbo, et al.
Publicado: (2013)

The RECQL helicase prevents replication fork collapse during replication stress
por: Benedict, Bente, et al.
Publicado: (2020)

RECQL5 plays co-operative and complementary roles with WRN syndrome helicase
por: Popuri, Venkateswarlu, et al.
Publicado: (2013)

RECQL5 plays co-operative and complementary roles with WRN syndrome helicase
por: Popuri, Venkateswarlu, et al.
Publicado: (2017)

Altered RECQL5 expression in urothelial bladder carcinoma increases cellular proliferation and makes RECQL5 helicase activity a novel target for chemotherapy
por: Patterson, Karl, et al.
Publicado: (2016)

The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability
por: Singh, Dharmendra Kumar, et al.
Publicado: (2012)

The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients
por: Jensen, Martin Borch, et al.
Publicado: (2012)

Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5
por: Kassube, Susanne A., et al.
Publicado: (2013)

RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1
por: Abu-Libdeh, Bassam, et al.
Publicado: (2022)

Enrichment of heterozygous germline RECQL4 loss-of-function variants in pediatric osteosarcoma
por: Maciaszek, Jamie L., et al.
Publicado: (2019)

BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells
por: Baker, Emma K, et al.
Publicado: (2015)

The N-terminus of the human RecQL4 helicase is a homeodomain-like DNA interaction motif
por: Ohlenschläger, Oliver, et al.
Publicado: (2012)

RECQL1 and WRN DNA repair helicases: potential therapeutic targets and proliferative markers against cancers
por: Futami, Kazunobu, et al.
Publicado: (2015)

Hyperubiquitylation of DNA helicase RECQL4 by E3 ligase MITOL prevents mitochondrial entry and potentiates mitophagy
por: Hussain, Mansoor, et al.
Publicado: (2023)

RECQL1 DNA Repair Helicase: A Potential Therapeutic Target and a Proliferative Marker against Ovarian Cancer
por: Sanada, Sakiko, et al.
Publicado: (2013)

Aberrantly Expressed RECQL4 Helicase Supports Proliferation and Drug Resistance of Human Glioma Cells and Glioma Stem Cells
por: Król, Sylwia K., et al.
Publicado: (2020)

Terminal osteoblast differentiation, mediated by runx2 and p27(KIP1), is disrupted in osteosarcoma
por: Thomas, David M., et al.
Publicado: (2004)

RECQL5 at the Intersection of Replication and Transcription
por: Hamadeh, Zeid, et al.
Publicado: (2020)

mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis
por: Martin, Sally K., et al.
Publicado: (2018)

A Large Case-Control Study Performed in Spanish Population Suggests That RECQL5 Is the Only RECQ Helicase Involved in Breast Cancer Susceptibility
por: Marchena-Perea, Erik Michel, et al.
Publicado: (2022)

Human RECQL1 participates in telomere maintenance
por: Popuri, Venkateswarlu, et al.
Publicado: (2014)

Human RECQL1 participates in telomere maintenance
por: Popuri, Venkateswarlu, et al.
Publicado: (2017)

Non‐enzymatic function of WRN RECQL helicase regulates removal of topoisomerase‐I‐DNA covalent complexes and triggers NF‐κB signaling in cancer
por: Gupta, Pooja, et al.
Publicado: (2022)

Mutations in RECQL Gene Are Associated with Predisposition to Breast Cancer
por: Sun, Jie, et al.
Publicado: (2015)

RecQ-like helicase 4 (RECQL4) exacerbates resistance to oxaliplatin in colon adenocarcinoma via activation of the PI3K/AKT signaling pathway
por: Zhou, Fei, et al.
Publicado: (2021)

Direct Inhibition of RNA Polymerase II Transcription by RECQL5
por: Aygün, Ozan, et al.
Publicado: (2009)

Human RECQL5β stimulates flap endonuclease 1
por: Speina, Elżbieta, et al.
Publicado: (2010)

Human RECQL5 participates in the removal of endogenous DNA damage
por: Tadokoro, Takashi, et al.
Publicado: (2012)

Clinical implications of germline mutations in breast cancer genes: RECQL
por: Bowden, A. Ramsay, et al.
Publicado: (2019)

Ciliary neurotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure
por: Askmyr, Maria, et al.
Publicado: (2015)

Upregulation of RECQL4 expression predicts poor prognosis in hepatocellular carcinoma
por: Li, Jun, et al.
Publicado: (2018)

Role and Regulation of the RECQL4 Family during Genomic Integrity Maintenance
por: Luong, Thong T., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_oe0lao82drp08r8crdk619nble