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Carbidopa-Based Modulation of the Functional Effect of the AAV2-hAADC Gene Therapy in 6-OHDA Lesioned Rats
Progressively blunted response to L-DOPA in Parkinson’s disease (PD) is a critical factor that complicates long-term pharmacotherapy in view of the central importance of this drug in management of the PD-related motor disturbance. This phenomenon is likely due to progressive loss of one of the key e...
Autores principales: | Ciesielska, Agnieszka, Sharma, Nitasha, Beyer, Janine, Forsayeth, John, Bankiewicz, Krystof |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393141/ https://www.ncbi.nlm.nih.gov/pubmed/25860990 http://dx.doi.org/10.1371/journal.pone.0122708 |
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