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15-Deoxy-Δ(12,14)-Prostaglandin J(2) Inhibits Osteolytic Breast Cancer Bone Metastasis and Estrogen Deficiency-Induced Bone Loss

Breast cancer is the major cause of cancer death in women worldwide. The most common site of metastasis is bone. Bone metastases obstruct the normal bone remodeling process and aberrantly enhance osteoclast-mediated bone resorption, which results in osteolytic lesions. 15-deoxy-Δ(12,14)-prostaglandi...

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Detalles Bibliográficos
Autores principales: Kim, Ki Rim, Kim, Hyun Jeong, Lee, Sun Kyoung, Ma, Gwang Taek, Park, Kwang Kyun, Chung, Won Yoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393227/
https://www.ncbi.nlm.nih.gov/pubmed/25859665
http://dx.doi.org/10.1371/journal.pone.0122764