Two-Dimensional Zymography Differentiates Gelatinase Isoforms in Stimulated Microglial Cells and in Brain Tissues of Acute Brain Injuries

Excessive activation of gelatinases (MMP-2/-9) is a key cause of detrimental outcomes in neurodegenerative diseases. A single-dimension zymography has been widely used to determine gelatinase expression and activity, but this method is inadequate in resolving complex enzyme isoforms, because gelatin...

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Detalles Bibliográficos
Autores principales: Chen, Shanyan, Meng, Fanjun, Chen, Zhenzhou, Tomlinson, Brittany N., Wesley, Jennifer M., Sun, Grace Y., Whaley-Connell, Adam T., Sowers, James R., Cui, Jiankun, Gu, Zezong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393235/
https://www.ncbi.nlm.nih.gov/pubmed/25859655
http://dx.doi.org/10.1371/journal.pone.0123852

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393235/
https://www.ncbi.nlm.nih.gov/pubmed/25859655
http://dx.doi.org/10.1371/journal.pone.0123852

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