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Two-Dimensional Zymography Differentiates Gelatinase Isoforms in Stimulated Microglial Cells and in Brain Tissues of Acute Brain Injuries

Excessive activation of gelatinases (MMP-2/-9) is a key cause of detrimental outcomes in neurodegenerative diseases. A single-dimension zymography has been widely used to determine gelatinase expression and activity, but this method is inadequate in resolving complex enzyme isoforms, because gelatin...

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Detalles Bibliográficos
Autores principales:	Chen, Shanyan, Meng, Fanjun, Chen, Zhenzhou, Tomlinson, Brittany N., Wesley, Jennifer M., Sun, Grace Y., Whaley-Connell, Adam T., Sowers, James R., Cui, Jiankun, Gu, Zezong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393235/ https://www.ncbi.nlm.nih.gov/pubmed/25859655 http://dx.doi.org/10.1371/journal.pone.0123852

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