Cargando…

Genome-wide blood DNA methylation alterations at regulatory elements and heterochromatic regions in monozygotic twins discordant for obesity and liver fat

BACKGROUND: The current epidemic of obesity and associated diseases calls for swift actions to better understand the mechanisms by which genetics and environmental factors affect metabolic health in humans. Monozygotic (MZ) twin pairs showing discordance for obesity suggest that epigenetic influence...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ollikainen, Miina, Ismail, Khadeeja, Gervin, Kristina, Kyllönen, Anjuska, Hakkarainen, Antti, Lundbom, Jesper, Järvinen, Elina A, Harris, Jennifer R, Lundbom, Nina, Rissanen, Aila, Lyle, Robert, Pietiläinen, Kirsi H, Kaprio, Jaakko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393626/ https://www.ncbi.nlm.nih.gov/pubmed/25866590 http://dx.doi.org/10.1186/s13148-015-0073-5

Ejemplares similares

Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI
por: van der Kolk, Birgitta W., et al.
Publicado: (2021)

Upregulation of Early and Downregulation of Terminal Pathway Complement Genes in Subcutaneous Adipose Tissue and Adipocytes in Acquired Obesity
por: Kaye, Sanna, et al.
Publicado: (2017)

Evaluation of the effect of donor weight on adipose stromal/stem cell characteristics by using weight-discordant monozygotic twin pairs
por: Juntunen, Miia, et al.
Publicado: (2021)

Global Transcript Profiles of Fat in Monozygotic Twins Discordant for BMI: Pathways behind Acquired Obesity
por: Pietiläinen, Kirsi H, et al.
Publicado: (2008)

Acquired Obesity Is Associated with Changes in the Serum Lipidomic Profile Independent of Genetic Effects – A Monozygotic Twin Study
por: Pietiläinen, Kirsi H., et al.
Publicado: (2007)

Biological clocks and physical functioning in monozygotic female twins
por: Sillanpää, Elina, et al.
Publicado: (2018)

An integrative machine learning approach to discovering multi-level molecular mechanisms of obesity using data from monozygotic twin pairs
por: Kibble, Milla, et al.
Publicado: (2020)

Abdominal adipose tissue and liver fat imaging in very low birth weight adults born preterm: birth cohort with sibling-controls
por: Kuula, Juho, et al.
Publicado: (2022)

BMI is positively associated with accelerated epigenetic aging in twin pairs discordant for body mass index
por: Lundgren, Sara, et al.
Publicado: (2022)

Liraglutide treatment improves postprandial lipid metabolism and cardiometabolic risk factors in humans with adequately controlled type 2 diabetes: A single‐centre randomized controlled study
por: Matikainen, Niina, et al.
Publicado: (2018)

Cardiac steatosis and left ventricular function in men with metabolic syndrome
por: Nyman, Kristofer, et al.
Publicado: (2013)

An Investigation into the Relationship Between Soft Tissue Body Composition and Bone Mineral Density in a Young Adult Twin Sample
por: Bogl, Leonie H, et al.
Publicado: (2011)

Phosphorylated IGFBP-1 as a non-invasive predictor of liver fat in NAFLD
por: Petäjä, Elina M., et al.
Publicado: (2016)

Modeling dependency structures in 450k DNA methylation data
por: Nustad, Haakon E, et al.
Publicado: (2021)

Transglutaminases and Obesity in Humans: Association of F13A1 to Adipocyte Hypertrophy and Adipose Tissue Immune Response
por: Kaartinen, Mari T., et al.
Publicado: (2020)

Differentially Methylated DNA Regions in Monozygotic Twin Pairs Discordant for Rheumatoid Arthritis: An Epigenome-Wide Study
por: Svendsen, Anders J., et al.
Publicado: (2016)

DNA Methylation and Gene Expression Changes in Monozygotic Twins Discordant for Psoriasis: Identification of Epigenetically Dysregulated Genes
por: Gervin, Kristina, et al.
Publicado: (2012)

Body electrical loss analysis (BELA) in the assessment of visceral fat: a demonstration
por: Blomqvist, Kim H, et al.
Publicado: (2011)

Physical activity and health: Findings from Finnish monozygotic twin pairs discordant for physical activity
por: Kujala, Urho M., et al.
Publicado: (2022)

Modified Atkins diet induces subacute selective ragged‐red‐fiber lysis in mitochondrial myopathy patients
por: Ahola, Sofia, et al.
Publicado: (2016)

The role of adolescent lifestyle habits in biological aging: A prospective twin study
por: Kankaanpää, Anna, et al.
Publicado: (2022)

Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome
por: Lovric, Alen, et al.
Publicado: (2018)

Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study
por: Lapatto, Helena A. K., et al.
Publicado: (2023)

Influence of Serotonin Transporter Gene Polymorphism (5-HTTLPR Polymorphism) on the Relation between Brain 5-HT Transporter Binding and Heart Rate Corrected Cardiac Repolarization Interval
por: Kauppila, Esa, et al.
Publicado: (2013)

Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning
por: Sillanpää, Elina, et al.
Publicado: (2021)

Discordant Keratoconus in Monozygotic Twins
por: Bitton, Karen, et al.
Publicado: (2022)

Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) – an 11-Year Prospective Study
por: Lallukka, Susanna, et al.
Publicado: (2017)

Systemic cross-talk between brain, gut, and peripheral tissues in glucose homeostasis: effects of exercise training (CROSSYS). Exercise training intervention in monozygotic twins discordant for body weight
por: Heiskanen, Marja A., et al.
Publicado: (2021)

Mortality Associations With DNA Methylation-Based Biological Aging and Physical Functioning Measures Across a 20-Year Follow-up Period
por: Föhr, Tiina, et al.
Publicado: (2023)

Lymphoma-Associated Biomarkers Are Increased in Current Smokers in Twin Pairs Discordant for Smoking
por: Wang, Jun, et al.
Publicado: (2021)

Leisure-time physical activity and DNA methylation age—a twin study
por: Sillanpää, Elina, et al.
Publicado: (2019)

Does the epigenetic clock GrimAge predict mortality independent of genetic influences: an 18 year follow-up study in older female twin pairs
por: Tiina, Föhr, et al.
Publicado: (2021)

Correction to: Does the epigenetic clock GrimAge predict mortality independent of genetic influences: an 18 year follow-up study in older female twin pairs
por: Föhr, Tiina, et al.
Publicado: (2021)

The Association Between Epigenetic Clocks and Physical Functioning in Older Women: A 3-Year Follow-up
por: Föhr, Tiina, et al.
Publicado: (2021)

The associations of long-term physical activity in adulthood with later biological ageing and all-cause mortality – a prospective twin study
por: Kankaanpää, Anna, et al.
Publicado: (2023)

Use of Genome-Wide Expression Data to Mine the “Gray Zone” of GWA Studies Leads to Novel Candidate Obesity Genes
por: Naukkarinen, Jussi, et al.
Publicado: (2010)

Epigenetics of discordant monozygotic twins: implications for disease
por: Castillo-Fernandez, Juan E, et al.
Publicado: (2014)

Leisure-Time and Occupational Physical Activity Associates Differently with Epigenetic Aging
por: KANKAANPÄÄ, ANNA, et al.
Publicado: (2021)

Do Epigenetic Clocks Provide Explanations for Sex Differences in Life Span? A Cross-Sectional Twin Study
por: Kankaanpää, Anna, et al.
Publicado: (2021)

Body mass index and subjective well-being in young adults: a twin population study
por: Linna, Milla S, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_bif7h5io7ok7rht74tjaplesot