Identification of a cluster-situated activator of oxytetracycline biosynthesis and manipulation of its expression for improved oxytetracycline production in Streptomyces rimosus

BACKGROUND: Oxytetracycline (OTC) is a broad-spectrum antibiotic commercially produced by Streptomyces rimosus. Despite its importance, little is known about the regulation of OTC biosynthesis, which hampered any effort to improve OTC production via engineering regulatory genes. RESULTS: A gene enco...

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Detalles Bibliográficos
Autores principales: Yin, Shouliang, Wang, Weishan, Wang, Xuefeng, Zhu, Yaxin, Jia, Xiaole, Li, Shanshan, Yuan, Fang, Zhang, Yuxiu, Yang, Keqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393881/
https://www.ncbi.nlm.nih.gov/pubmed/25886456
http://dx.doi.org/10.1186/s12934-015-0231-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393881/
https://www.ncbi.nlm.nih.gov/pubmed/25886456
http://dx.doi.org/10.1186/s12934-015-0231-7

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