Comparative Modeling and Molecular Dynamics Simulation of Substrate Binding in Human Fatty Acid Synthase: Enoyl Reductase and β-Ketoacyl Reductase Catalytic Domains

Fatty acid synthase (FASN, EC 2.3.1.85), is a multi-enzyme dimer complex that plays a critical role in lipogenesis. This lipogenic enzyme has gained importance beyond its physiological role due to its implications in several clinical conditions-cancers, obesity, and diabetes. This has made FASN an a...

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Detalles Bibliográficos
Autores principales: John, Arun, Umashankar, Vetrivel, Krishnakumar, Subramanian, Deepa, Perinkulam Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korea Genome Organization 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394236/
https://www.ncbi.nlm.nih.gov/pubmed/25873848
http://dx.doi.org/10.5808/GI.2015.13.1.15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394236/
https://www.ncbi.nlm.nih.gov/pubmed/25873848
http://dx.doi.org/10.5808/GI.2015.13.1.15

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