G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases

Dephosphorylation of eukaryotic translation initiation factor 2a (eIF2a) restores protein synthesis at the waning of stress responses and requires a PP1 catalytic subunit and a regulatory subunit, PPP1R15A/GADD34 or PPP1R15B/CReP. Surprisingly, PPP1R15-PP1 binary complexes reconstituted in vitro lac...

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Detalles Bibliográficos
Autores principales: Chen, Ruming, Rato, Cláudia, Yan, Yahui, Crespillo-Casado, Ana, Clarke, Hanna J, Harding, Heather P, Marciniak, Stefan J, Read, Randy J, Ron, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394352/
https://www.ncbi.nlm.nih.gov/pubmed/25774600
http://dx.doi.org/10.7554/eLife.04871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394352/
https://www.ncbi.nlm.nih.gov/pubmed/25774600
http://dx.doi.org/10.7554/eLife.04871

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